A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. She has 14 years of experience in Clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students. However, the evidence is conflicting. Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. 2012;308(3):274-282. doi:10.1001/jama.2012.8265. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Researchers think it may also slow down the growth of cancer cells. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Of the total drug interactions, 3 are moderate, and 1 is minor. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. In animal studies, the antioxidant and radical-scavenging properties of silibinin in milk thistle were found to reduce tumors (16). Others may find them inefficient, while some people swear by them. We explore the potential health benefits of milk thistle below. The following two tabs change content below. Studies show that silymarin may help ease inflammation and promote cell repair. Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. However, consult your doctor for the best advice. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity, Drug Metabolsim and Disposition, US National Library of Medicine, National Institutes of Health. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. The common name, milk thistle, is derived from the "milky white" veins on the leaves, which, when broken open, yield a milky sap. What Happens If I Take Too Much Milk Thistle? 1982;17:51721. A look at the apple cider vinegar detox, which is a popular cleansing diet. Taking it along with estrogen pills might reduce their effectiveness. Talk to your pharmacist for more details. Over-indulging in this powerful herb may do you more harm than you know. The terms "milk thistle" and "silymarin" are often used interchangeably. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. However, the extracts in milk thistle could act like estrogen. But it may be a helpful complementary treatment to try if a healthcare professional approves it. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. Scientists think this creates a detoxifying effect, which is why milk thistle may be beneficial for liver problems. The active ingredient in milk thistle is called silymarin. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. Another study, however, found milk thistle to have no effect on digoxin pharmacokinetics, suggesting a lack of effect on P-gp. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. Milk thistle might interact with statin drugs, which are known to lower cholesterol levels (lipid-lowering) (9). In: StatPearls. These combination supplements may list health claims on the label. Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. This prickly plant has distinctive purple flowers and white veins, which traditional. Mulrow C, Lawrence V, Jacobs B, et al. The terms milk thistle and silymarin are often used interchangeably. Current studies on milk thistle use a wide range of doses. These reactions may occur if you have an allergy to milk thistle. Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. In a 2016 study, researchers fed rats a high-cholesterol diet. An important part of taking supplements is proper storage. Researchers must carry out further studies on humans to identify what benefits a person can expect from applying milk thistle to their skin. Milk thistle is native to Europe and was introduced into North America by early colonists. Scan J Gastroenterol. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox. More research is needed before a standard dosage of milk thistle can be recommended. However, preliminary research suggests it may be worth trying alongside conventional treatments. If you have any questions about storage, ask your pharmacist. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. Some people also call it Mary thistle and holy thistle. There are no guidelines regarding a standard dose of milk thistle. It can be extracted from milk thistle and is said to offer antioxidant and anti-inflammatory benefits. Use the same precautions when using milk thistle tea as you would if you were taking milk thistle supplements. Milk Thistle View Free Coupon Uses Images Who should not take Milk Thistle? Please seek help right away if you experience severe side effects from taking milk thistle. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Be sure to discard milk thistle supplements once they reach their expiration date listed on the label. Some of these drugs may include Mevacor, Lescol, Zocor, Pravachol, and Baycol. Learn more about the other negative effects of this herb and what research says about them. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. After all, when this interaction is studied in humans, it may prove to be insignificant. Keep in mind, though, that it is unknown if milk thistle tea provides the same suggested benefits as milk thistle supplements. Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. JAMA. Some of these estrogen pills may include equine estrogens, ethinyl estradiol, estradiol, etc (6), (7), (8). Calm an upset stomach. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. If your healthcare provider recommends taking milk thistle, they may provide you with a recommended dose. How long does it take for milk thistle to start working? Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. The medical community needs more evidence to prove that milk thistle benefits human livers in the same way. No supplement is intended to treat, cure, or prevent disease. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs -- such as fexofenadine (Allegra) Drugs for high cholesterol -- such as lovastatin (Mevacor, Altocor) Last medically reviewed on December 17, 2021. Although rare, milk thistle may trigger a number of common and mild side effects. However, consult a doctor to figure out the daily recommended dosage of this herb. Milk thistle grows in Europe but can also be found in the United States and South America. Get emergency medical help if you have any of these signs of an allergic reaction while taking milk thistle: hives; difficult breathing; swelling of your face, lips, tongue, or throat. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. de Avelar CR, Pereira EM, de Farias Costa PR, et al. Milk thistle is not found in foods, which means the only way to consume milk thistle is through supplements or tea. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. Milk thistle interacts with these drugs as both are broken down by the same liver enzymes. It is also unknown whether milk thistle is safe for children. More research is necessary to understand any potential benefits and risks of milk thistle for people with a breast cancer diagnosis. The active ingredient in milk thistle may help to reduce inflammation. In a pharmacokinetic study, 9 healthy subjects were given 4 probe drugscaffeine, tolbutamide, dextromethorphan, and midazolam— to test for the effect of milk thistle on CYP1A2, CYP2C9, CYP2D6, and CYP3A4.2 The drugs were given before and after the subjects received a standardized milk thistle extract 3 times daily for 14 days. 3. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. However, there is no solid evidence that supports these claims. (2021). What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. A double-blind controlled study. Allergic reactions, abdominal problems, and estrogen and drug interactions are some of the common side effects seen in people who take this herb for extended durations. This product is not recommended for use during pregnancy. This is not a complete list of side effects and others may occur. Things to remember when you fill your prescription. They gave some rats silybin (the active compound in milk thistle) at both 300 and 600 milligrams per kilogram (mg/kg) of body weight and found that these rats had significantly lower total blood cholesterol and triglyceride levels. Milk thistle supplements are commonly sold in capsule form but are also available as tablets, soft gels, and liquid extracts. content is best viewed in IE9 or above, Firefox and Google Chrome browser. Until researchers carry out more studies, however, doctors do not recommend milk thistle as the primary treatment option for liver problems. Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. 2016;5147468. doi:10.1155/2016/5147468. More study is needed to confirm this. Also known by its scientific name, Silybum marianum, milk thistle grows mostly in California, although it can be grown in many other warm climates as well. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Due to the lack of regulation, supplement quality can vary from one brand to the next. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding. Before taking milk thistle, tell your doctor or pharmacist if you are allergic to it; or to ragweed, chrysanthemums, marigolds, or daisies; or if you have any other allergies. Consult your healthcare provider if this applies to you. Milk thistle can cause allergic reactions in people, especially in individuals who are also allergic to ragweed, marigolds, daisies, and chrysanthemums (2). Medical News Today only shows you brands and products that we stand behind. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. You should follow dosage directions to prevent side effects. The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. Conventional treatments approaches you use a doctor to figure out the best way to proceed thistle were found to tumors... Applies to you form but are also available as tablets, soft,... 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